Gary is an 8-year-old neutered male Yorkshire Terrier whose owners took him to his regular veterinarian when they noticed he was intermittently vomiting and having diarrhea. Gary’s veterinarian found that he had hypoproteinemia and abdominal effusion and referred him to Veterinary Referral Hospital of Hickory.
Gary came through Veterinary Referral Hospital of Hickory’s emergency service, where an emergency veterinarian performed a physical exam and ran bloodwork. Gary had good body condition, but his fur was dull and dry, and he had some abdominal distension. He weighed in at 10.9 pounds. His incoming blood work identified a panhypoproteinemia, hypocholesterolemia, a low total calcium, and mild leukocytosis. Lab work competed by the emergency service identified:
|BE, ECF||-0.5||-5.0-5.0 mmol/L|
|Calcium, ionized||0.77||1.13-1.42 mmol/L|
|Anion gap||10||5-22 mmol/L|
The emergency doctor started Gary on IV fluids, administering:
- 45% NaCl + 2.5% dextrose + 20mEq KCl/L @mtn
- IV Hetastarch 4 cc/hr
- SQ Cerenia 0.5 cc SID
- IV Protonix -.7 mg/kg SID
- Administer IV Mg/Ca over 12 hrs:
- 1 mEq/Kg/24 hr Mg
- 1 ml/kg/Ca Gluconate 10% diluted in D5W
TPR is normal, ate RCLF well
Dr. Helms sees Gary for the first time on this day, performs a comprehensive exam, and continues to monitor his bloodwork. His exam revealed a distended abdomen and a grade III medial patellar luxation on the left.
The fluid therapy is working and Gary’s bloodwork starts to normalize. Blood protein levels are up. His lab work at noon showed:
|BE, ECF||-0.6||-5.0-5.0 mmol/L|
|Calcium, ionized||1.04||1.13-1.42 mmol/L|
|Anion gap||16||5-22 mmol/L|
Dr. Helms continues Gary’s fluid therapy, including calcium gluconate and magnesium sulfate to resolve the low calcium and magnesium blood levels. He continues to monitor Gary’s bloodwork to look for response to the fluid therapy.
At this time, the main concern for Gary is his low protein levels. Low protein can be an effect of various conditions. Gary’s weight and body condition do not suggest emaciation, and there are no indications of kidney disease. As such, Dr. Helms began looking for the next cause: a GI issue, which is consistent with Gary’s vomiting and diarrhea.
Dr. Helms performed an ultrasound on Gary, which showed some free fluid in the abdomen and mesenteric thickening. Gary’s kidneys, bladder, adrenal glands, and spleen appeared normal. Gary’s liver was enlarged and the edges rounded, and gall bladder distended without evidence of extrahepatic biliary tract obstruction. Dr. Helms identified diffuse thickening of the wall of the small intestine, but there was no visible evidence of cancer. Abdominal lymph nodes appeared normal.
Dr. Helms took a urine sample to be submitted for urinalysis including urinary protein/creatinine ratio, and blood for bile acids. Dr. Helms updated Gary’s rDVM at this point, and Gary was monitored overnight.
Gary is quiet, alert, and responsive. He has had no vomiting or diarrhea but was still on medication to prevent both. His abdomen remained distended.
Lab work on this day showed:
|BE, ECF||-2.1||-5.0-5.0 mmol/L|
|Calcium, ionized||1.08||1.13-1.42 mmol/L|
|Anion gap||16||5-22 mmol/L|
|Total protein||2.6||5.5-7.6 g/dl|
|Globulin||No result available||2.0-3.6 g/dl|
With the ultrasound not definitive, Dr. Helms schedules an endoscopy of Gary’s GI tract to take biopsies. At this point, considerations for Gary’s underlying condition include:
- Inflammatory bowel disease
- Liver disease
Pre-med: Butorphanol (10mg/ml) 0.8 mg
Induction: Propofol (10 mg-ml) 17.5 mg IV
Intra-op medications: atropine (0.5 mg-ml) 125 mcg IV
Intra-op fluids: LRS 21 ml/hr and hetastarch at 4 ml/hr IV
The endoscopy showed a normal esophagus, but increased granularity was noted in the gastric body and fundus. There was also increased granularity and friability in the duodenum. Biopsy samples were taken of the stomach and duodenum and sent to Idexx for histopathology.
Gary’s urinalysis showed:
|Bilirubin||Negative||Neg to 1+|
|Struvite (MgNH4PO4) crystals||2-3|
|Squamous epithelia||0-1||0-3 HPF|
|Protein/creatinine ratio||0.3||<+ 0.5 ratio|
Over the next four days, Dr. Helms monitors Gary, taking bloodwork each day to look for improvement. His low levels rise and stabilize. Gary’s biopsy results were as follows:
Duodenum: Multiple small sections of small intestinal mucosa are examined. There are mildly to moderately increased numbers of lymphocytes and plasma cells within the lamina propria, with 5 to 7 mononuclear cells sometimes separating crypts. Crypts are occasionally mildly to moderately dilated and contain luminal eosinophilic proteinase material with admixed cellular debris (crypt abscesses). Rare globule leukocytes are also noted. Normal villous architecture is present, and no infectious organisms are observed. There is no evidence of lymphangiectasia.
Stomach: The examined gastric samples consist of antrum, gastric body, and fundus. Mucosal lymphoid follicles within the pyloric antrum are often mildly hyperplastic. There is mild edema of the lamina propria, with mildly increased numbers of scattered lymphocytes and plasma cells. Samples from the gastric body are characterized by mild edema of the superficial lamina propria. Samples from the fundus are characterized by mildly increased numbers of lymphocytes and plasma cells scattered throughout the lamina propria. There is no evidence of erosion/ulceration, fibrosis, or neoplasia, and no infectious organisms are observed.
Duodenum: Mild to moderate lymphoplasmacytic mucosal enteritis
Stomach: Mild lymphoplasmacytic mucosal gastritis with edema and lymphoid hyperplasia
Dr. Helms gives Gary a definitive diagnosis of lymphoplasmacytic enteritis causing his panhypoproteinemia. The exact cause of lymphoplasmacytic enteritis is not known. It has been speculated that genetics, food allergies, intestinal parasites, and intestinal bacteria; each has the potential to cause IBD.
Gary responded to supportive care and improved significantly during his time at Veterinary Referral Hospital of Hickory. His blood work on the final day showed:
|BE, ECF||2.5||-5.0-5.0 mmol/L|
|Calcium, ionized||1.28||1.13-1.42 mmol/L|
|Anion gap||15||5-22 mmol/L|
|Total protein||3.4||5.5-7.6 g/dl|
Dr. Helms recommended a hypoallergenic diet (K-9 Z/D can, 5.5 oz, feed 1 2/3 to 2 cans daily), plus:
- Prednisone: 5 mg, #30. 1 tab by mouth morning and evening.
- Metronidazole: 250 mg, #1.5. ¼ tab given by mouth morning and evening.
- Omeprazole DR: 10 mg, #30. 1 capsule by mouth every 24 hours, continue while on prednisone.
- Cernia: 16 mg, #1. ½ tab by mouth as needed. Can be given for four consecutive days, then skip one day before starting again.
Dr. Helms schedules Gary for a recheck in one week.
For consultations or referrals to Veterinary Referral Hospital of Hickory, please call us at 828.328.6697.